Stricter nutrient regulations and increasingly variable influent quality are challenging the stability and performance of biological nutrient removal (BNR) processes. This presentation introduces nanobubble technology as a practical process intensification tool that enhances biological activity and treatment stability within existing infrastructure. Nanobubbles—nanosized, stable bubbles (<200 nm) with high surface charge and neutral buoyancy—exert a catalytic effect on biological processes by improving enzymatic activity, increasing substrate–microbe contact, and strengthening floc structure. Their interfacial properties reduce the inhibitory impact of surfactants, fats/oils/grease, and other compounds that disrupt microbial pathways and solids separation. These effects support more robust nitrification–denitrification performance across activated sludge processes. Full-scale applications have demonstrated 25–40% higher nitrogen removal, 15–40% lower aeration energy, 10–100% reduction or elimination of chemical use, and up to 25% more biogas, enabling utilities to increase capacity and maintain compliance without new tankage. The session will share integration strategies, operating envelopes, and control considerations, supported by performance data from full-scale installations.