Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants associated with significant health and environmental risks. Conventional PFAS treatment technologies often show limited performance for short-chain PFAS and in complex water matrices. Chromafora has developed SELPAXT, a water treatment technology based on Surfactant-Ligand Assisted Membrane Filtration (SAMF), designed to overcome these limitations. This study evaluates SELPAXT’s ability to remove a broad spectrum of PFAS, including short-chain compounds, from contaminated water streams. SELPAXT chemically and physically retains PFAS on an ultrafiltration membrane, supported by continuous chemical dosing to ensure stable performance. The technology was evaluated in pilot and full-scale installations at landfill leachate and industrial groundwater sites. Performance metrics included PFAS removal efficiency, robustness in complex matrices, and efficiency of automatic system regeneration. SELPAXT achieved consistently high PFAS removal, exceeding 90% for short-chain PFAS (C4–C6) and up to 97% total PFAS reduction in full-scale operation. The system demonstrated strong tolerance to organic matter and suspended solids with minimal pre-treatment requirements. Residual waste generation was low, producing concentrate volumes of only 0.1–1% of treated water. These results confirm SELPAXT as a scalable, energy-efficient, and sustainable solution for PFAS remediation across diverse water types.