Many developing countries, like Ghana, are facing growing pressure on freshwater resources due to population growth, rapid urbanization, and climate variability. One practical solution is the reuse of treated wastewater, which can support agriculture and industry and help prevent drought impacts. This study examined the potential and benefits of water reuse in peri-urban areas of the Greater Accra Region. The study combined field sampling of treated effluents (n = 12), water quality testing, and stakeholder interviews. The results showed that treated effluent meets standards for crop irrigation and non-potable industrial use, with nutrient content sufficient to reduce fertilizer use by 15 to 20% and water availability improved by 18% during dry periods (p < 0.01). The key challenges include limited storage infrastructure, technical capacity, and gaps in regulation. By using nature-based solutions, such as constructed wetlands for additional treatment would further improve water quality while supporting local ecosystems. The study demonstrated that combining data-driven planning with local knowledge can make wastewater reuse a reliable, resilient, and sustainable resource. These insights provided practical guidance for policymakers, donors, and utilities seeking to strengthen water security, improve resource efficiency, and advance sustainable development in Ghana and developing countries. Key words: Wastewater Reuse, Water Security, Nature-Based Solutions, Resource Efficiency, Developing Countries