Emerging contaminants (ECs) such as antibiotics in wastewaters are of global concern with 'One Health' implications. Removal of these contaminants prior to release of effluent to environmental waters may help reduce spread of antimicrobial resistance (AMR) in the environment. Wastewater treatment works were not designed to remove these contaminants, therefore there is a need to develop technologies to improve water quality and reuse. The revised Urban Wastewater Treatment Directive (EU, 2024) includes AMR surveillance as a requirement for member states by 2030, further emphasising the pertinence of this topic. Sorption-based technologies such as granular activated carbon (GAC) or powdered activated carbon (PAC) and nanomaterials that include metal-organic frameworks (MOFs) and layered double hydroxides (LDHs) can be used to reduce the concentration of ECs in water. It is important to ensure the robustness and suitability of materials for wastewater treatment as well as ensuring the materials do not have adverse effects. Understanding antimicrobial activity of materials is important to understand potential mitigation or proliferation of AMR. The aim of this work is to characterise and investigate the antimicrobial properties of nanomaterials (MIL-100(Fe) – an iron-based MOF and Mg2Al-NO3 LDH – a magnesium- and aluminium-based LDH) for application in wastewater treatment for EC removal.